Hydroquinone was not safe for use in leaveon, nondrug cosmetic products. In the presence of air and moisture, hydroquinone dust may react to form irritating quinone which forms a vapor at room temperature. Safety data sheet according to 29cfr19101200 and ghs rev. First aid measures description of firstaid measures general advice. Material safety data sheet hydroquinone 2 ingestion. Ac12090, ac120910020, ac120910050, ac120915000, ac219930000, ac219930050 ac219930050, ac219930500, h329500 synonyms. View or download the hydroquinone msds material safety data sheet or sds for 822333 from milliporesigma. Chemical properties of hydroquinone cas 123319 download as pdf file download as excel file download as 2d mole file predict properties. May cause dizziness, nausea, sense of suffocation, increased respiratory rate, vomiting, pallor, muscle twitching, cyanosis bluish discoloration of skin due to deficient oxygenation of the blood, delirium.
The dust my cause irritation of the nose, throat and upper respiratory tract. This compound is a generalpurpose inhibitor, stabilizer, antioxidant, and intermediate. Product identifier product name hydroquinone product number fh01233 synonyms. Osha table z1 limits for air contaminants 29 cfr 1910. Rats and mice were given hydroquinone by stomach tube or at high concentrations in the diet. Melanin is the pigment in skin that gives it a brown color. Get medical adviceattention p310 immediately call a poison centerdoctor p330 if swallowed, rinse mouth. This staining is temporary and can typically be removed with soap and water washing, but its best to avoid benzoyl peroxidebased acne treatments and oxygeninfusing skin care treatments, which. May cause irritation of the nose and respiratory tract.
Substituted derivatives of this parent compound are also referred to as hydroquinones. May cause severe irritation of the digestive tract. It is formed in large quantities by chemical reduction of benzoquinone. It is topically applied to treat melisma, freckles and senile lentigines. Hydroquinone is commonly used as a biomarker for benzene exposure. Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates it also finds use in topical skin creams and lotions for reducing the signs of age. Hydroquinone is on the right to know hazardous substance list because it is cited by osha, acgih, dot, niosh, dep, iarc, nfpa and epa.
The guide is intended to supplement training, material safety data sheets msdss, safety. Exposure controlspersonal protection components with workplace control parameters components casno. Commission regulation eu no 2015830 of 28 may 2015. Acgih threshold limit values 01 2010 pel 2 mgm3 us. Hydroquinone has been detected in cigarette smoke mainstream and. Sigmaaldrich material safety data sheet date printed. Sewage sludge activated to phenol was found to oxidize hydroquinone 3,4. Hydroquinone also may be an important factor in the defense mechanis some insects, most notably the bombardier beetle hsdb, 2005 hydroquinone may be released into the environment during its produ. Achieve a more even tone with hydroquinone free skin lighteners and brighteners. Hydroquinone is an active allergen so repeated and prolonged exposure may cause skin sensitization. Hydroquinone safety data sheet according to federal register vol. Hydroquinone did not cause birth defects when given orally to pregnant rats at doses up to 300 mgkgday.
Show this safety data sheet to the doctor in attendance. Suspected of causing cancer very toxic to aquatic life precautionary statements. The frequency of fetal death was increase among rats fed 2500 mgkg of hydroquinone. All products should be stored at a dry and ventilated location away from fire and other dangerous goods, and should avoid direct sunlight. Amended safety assessment of hydroquinone as used in. Responses were not consistent across route of exposure, species or sex. Qualitative and quantitative estimation of hydroquinone in. Pure hydroquinone does not readily form a vapor at room temperature. Extinguishing media protective equipment and wear selfcontained breathing apparatus and protective clothing to prevent contact with skin and eyes. Hydroquinone can be found on the following state righttoknow lists. Value control parameters update basis hydroquinone 123319 twa 1 mgm3 20080101 usa.
It also finds use in topical skin creams and lotions for. Use of hydroquinone with any products containing benzoyl peroxide, hydrogen peroxide, or other peroxides may cause temporary staining of the skin. Hydroquinone, usp hydroquinone, usp sds preparation date 10172016. Sewage sludge activated to phenol was found to oxidize hydroquinone3,4. Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other. Clinical director, innovative skincare topical hydroquinone is used frequently throughout the world as a skin bleaching agent. Extrasynthese is a leading chemicals company that provides customers with highquality hydroquinone standard reference material. Material safety data sheet section 1 hydroquinone 1 chemical product and company identification msds name. Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates. Achieve a more even tone with hydroquinonefree skin lighteners and brighteners.
Chlorophacinone is a diarylmethane and a betatriketone. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 22 2016. Black and white bleaching cream with hydroquinone walgreens. A schimadzu lc9 was used with uv detector set at 295 nm having ods column 25 cm. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The rate of malformations was not significantly increased among the offspring of rabbits administered doses up to 150 mgkgday during pregnancy. No warranty, express or implied, is made and qorpak assumes no liability resulting from the use of this msds. Safety data sheet according to federal register vol. Skin darkening is called epidermal hyperpigmentation and is caused by the deposit of too much melanin normal skin pigment in the skin. Material safety data sheet hydroquinone 6 information in this msds is from available published sources and is believed to be accurate. Material safety data sheet west liberty university. Material safety data sheet eastman chemical company.
Hydroquinone reference material extrasynthese, hydroquinone. Hydroquinone is a phenolic compound, which is naturally found in coffee, tea and wine. Material safety data sheet hydroquinone msds section 1. Hydroquinone for cosmetic use is chemically synthesized.
Members of the ectonox family, such as cnox, or enox1, are involved in plasma membrane transport pathways. Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma. Commercially available as oil concentrate and as dust concentrate. Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other skin lightening ingredient compares to its effectiveness. Hydroquinone patient instructions what is hyperpigmentation. First aid eye contact immediately flush with large amounts of water for at least 30 minutes, lifting upper and lower lids. Amended safety assessment of hydroquinone as used in cosmetics.
Hydroquinone msds 822333 milliporesigma emd millipore. All products should be stored at a dry and ventilated location away from fire and. Over the past several years, hydroquinone has become a controversial skincare ingredient for topical use. You also can through below form to request documents for moa,ros,1hnmr. Identification of the substancemixture and of the companyundertaking 1.
Buy hydroquinone cas 123319, a quinone small molecule with efficacy as a topical preparation, from santa cruz. The presence of hydroquinone in normal individuals stems mainly from direct dietary. Chemical product and company identification product name. Hydroquinone, also known as benzene1, 4diol, is an aromatic organic compound which is a type of phenol, having the chemical formula c6h4oh2. The mobile phase was a mixture of water and ethanol 45. Registrationlogin is required to view the sheets which appear to be all in pdf format.
Headaches, dizziness, nausea, and cyanosis may result from overexposure to. Hydroquinone is linked to exogenous ochronosis, dermatitis and skin. Black and white bleaching cream with hydroquinone at walgreens. To go further in meeting our customers needs, certificates of analysis coa, material safety data sheets msds, and technical specifications are available for all our products online or upon request. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. The user must determine suitability of this information for his application. Hydroquinone according to regulation ec no 19072006, annex ii, as amended. It works by inhibiting an enzyme reaction in skin cells. The international agency for research on cancer iarc has classified hydroquinone in group 3, i. Shop lovelyskin for exclusive offers, free shipping and samples. Hydroquinone, also known as benzene1,4diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula c 6 h 4 oh 2. Pure culture oxidation of hydroquinone produced 1,4benzoquinone, 2hydroxy1,4benzoquinone and betaketoadipic acid5.
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